A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria

Tuberculosis remains one of the most deadly infectious diseases worldwide and is a leading public health problem. Although isoniazid (INH) is a key drug for the treatment of tuberculosis, tolerance to INH necessitates prolonged treatment, which is a concern for effective tuberculosis chemotherapy. I...

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Hauptverfasser: Niki, Makoto, Niki, Mamiko, Tateishi, Yoshitaka, Ozeki, Yuriko, Kirikae, Teruo, Lewin, Astrid, Inoue, Yusuke, Matsumoto, Makoto, Dahl, John L., Ogura, Hisashi, Kobayashi, Kazuo, Matsumoto, Sohkichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431685/
https://ncbi.nlm.nih.gov/pubmed/22648414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333385
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