Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers

The endosomal sorting complex required for transport (ESCRT) system traffics ubiquitinated cargo to lysosomes via an unusual membrane budding reaction that is directed away from the cytosol. Here, we show that human ESCRT-II self-assembles into clusters of 10–100 molecules on supported lipid bilayer...

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Bibliographic Details
Main Authors: Boura, Evzen, Ivanov, Vassili, Carlson, Lars-Anders, Mizuuchi, Kiyoshi, Hurley, James H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431677/
https://ncbi.nlm.nih.gov/pubmed/22718754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.378646
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