The Rates of Ca(2+) Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

The rate-limiting step of cardiac muscle relaxation has been proposed to reside in the myofilament. Both the rates of cross-bridge detachment and Ca(2+) dissociation from troponin C (TnC) have been hypothesized to rate-limit myofilament inactivation. In this study we used a fluorescent TnC to measur...

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Autores principales: Little, Sean C., Biesiadecki, Brandon J., Kilic, Ahmet, Higgins, Robert S. D., Janssen, Paul M. L., Davis, Jonathan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431663/
https://ncbi.nlm.nih.gov/pubmed/22718768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337295
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