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Modular Dispensability of Dysferlin C2 Domains Reveals Rational Design for Mini-dysferlin Molecules
Dysferlin is a large transmembrane protein composed of a C-terminal transmembrane domain, two DysF domains, and seven C2 domains that mediate lipid- and protein-binding interactions. Recessive loss-of-function mutations in dysferlin lead to muscular dystrophies, for which no treatment is currently a...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431656/ https://ncbi.nlm.nih.gov/pubmed/22736764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391722 |
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