Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

Mesangial and circulating IgA1 with aberrantly glycosylated hinge region O-glycans characterize IgA nephropathy (IgAN). Unlike healthy individuals, some IgA1 is galactose deficient in patients with IgAN, leaving terminal N-acetylgalactosamine residues in the hinge region exposed. Circulating autoant...

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Main Authors: Berthoux, Francois, Suzuki, Hitoshi, Thibaudin, Lise, Yanagawa, Hiroyuki, Maillard, Nicolas, Mariat, Christophe, Tomino, Yasuhiko, Julian, Bruce A., Novak, Jan
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2012
Assuntos:
Clinical Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431415/
https://ncbi.nlm.nih.gov/pubmed/22904352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012010053
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