A Common BACE1 Polymorphism Is a Risk Factor for Sporadic Creutzfeldt-Jakob Disease

The β site APP cleaving enzyme 1 (BACE1) is the rate-limiting β-secretase enzyme in the amyloidogenic processing of APP and Aβ formation, and therefore it has a prominent role in Alzheimer’s disease (AD) pathology. Recent evidence suggests that the prion protein (PrP) interacts directly with BACE1 r...

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Main Authors: Calero, Olga, Bullido, María J., Clarimón, Jordi, Frank-García, Ana, Martínez-Martín, Pablo, Lleó, Alberto, Rey, María Jesús, Sastre, Isabel, Rábano, Alberto, de Pedro-Cuesta, Jesús, Ferrer, Isidro, Calero, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431402/
https://ncbi.nlm.nih.gov/pubmed/22952813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043926
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