CXCR4 Inhibition with AMD3100 Sensitizes Prostate Cancer to Docetaxel Chemotherapy

Several in vitro and in vivo models have revealed the key role of CXCR4/CXCL12 axis in tumor-stroma interactions. Stromal cells present in the tumor microenvironment express high levels of CXCL12 protein, directly stimulating proliferation and migration of CXCR4-expressing cancer cells. This specifi...

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Bibliographic Details
Main Authors: Domanska, Urszula M, Timmer-Bosscha, Hetty, Nagengast, Wouter B, Oude Munnink, Thijs H, Kruizinga, Roeliene C, Ananias, Hildo JK, Kliphuis, Nathalie M, Huls, Gerwin, De Vries, Elisabeth GE, de Jong, Igle J, Walenkamp, Annemiek ME
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431178/
https://ncbi.nlm.nih.gov/pubmed/22952424
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