Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass

We tested the hypothesis that reactive oxygen species (ROS) contributed to renal hypoxia in C57BL/6 mice with ⅚ surgical reduction of renal mass (RRM). ROS can activate the mitochondrial uncoupling protein 2 (UCP-2) and increase O(2) usage. However, UCP-2 can be inactivated by glutathionylation. Mic...

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Detalhes bibliográficos
Main Authors: Lai, En Yin, Luo, Zaiming, Onozato, Maristela L., Rudolph, Earl H., Solis, Glenn, Jose, Pedro A., Wellstein, Anton, Aslam, Shakil, Quinn, Mark T., Griendling, Kathy, Le, Thu, Li, Ping, Palm, Fredrik, Welch, William J., Wilcox, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431146/
https://ncbi.nlm.nih.gov/pubmed/22492941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00005.2012
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