PR3 and Elastase Alter PAR1 Signaling and Trigger vWF Release via a Calcium-Independent Mechanism from Glomerular Endothelial Cells

Neutrophil proteases, proteinase-3 (PR3) and elastase play key roles in glomerular endothelial cell (GEC) injury during glomerulonephritis. Endothelial protease-activated receptors (PARs) are potential serine protease targets in glomerulonephritis. We investigated whether PAR1/2 are required for alt...

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Detalhes bibliográficos
Main Authors: Tull, Samantha P., Bevins, Anne, Kuravi, Sahithi Jyothsna, Satchell, Simon C., Al-Ani, Bahjat, Young, Stephen P., Harper, Lorraine, Williams, Julie M., Rainger, George Ed, Savage, Caroline O. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430624/
https://ncbi.nlm.nih.gov/pubmed/22952809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043916
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