Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI)

Current pharmacopeial methods for testing dry powder inhalers (DPIs) require that 4.0 L be drawn through the inhaler to quantify aerodynamic particle size distribution of “inhaled” particles. This volume comfortably exceeds the internal dead volume of the Andersen eight-stage cascade impactor (ACI)...

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Main Authors: Mohammed, Hlack, Roberts, Daryl L., Copley, Mark, Hammond, Mark, Nichols, Steven C., Mitchell, Jolyon P.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429667/
https://ncbi.nlm.nih.gov/pubmed/22678745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-012-9797-0
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