Pyrimidine nucleoside analogues.X. 5-Substituted 1-(1,3-dihydroxypropyl-2) uracils.

A convenient method is suggested for synthesis of uracil-1-malonic acid diethyl ester by alkylating 2,4-bis(trimethylsilyl) uracil with bromo-malonic acid diethyl ester. This compound has been shown to hydrolyze with NaOH yielding either uracil or uracil-1-acetic acid, depending on reaction conditio...

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Bibliographic Details
Main Authors: Hiller, S A, Zarin, D E, Zhuk, R A
Format: Artigo
Language:Inglês
Published: 1976
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC342936/
https://ncbi.nlm.nih.gov/pubmed/5709
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