Chemotherapy targeting by DNA capture in viral protein particles

AIM: This study tests the hypothesis that DNA intercalation and electrophilic interactions can be exploited to noncovalently assemble doxorubicin in a viral protein nanoparticle designed to target and penetrate tumor cells through ligand-directed delivery. We further test whether this new paradigm o...

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Detalhes bibliográficos
Main Authors: Agadjanian, Hasmik, Chu, David, Hwang, Jae Youn, Wachsmann-Hogiu, Sebastian, Rentsendorj, Altan, Song, Lei, Valluripalli, Vinod, Lubow, Jay, Ma, Jun, Sharifi, Behrooz, Farkas, Daniel L, Medina-Kauwe, Lali K
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429352/
https://ncbi.nlm.nih.gov/pubmed/22385197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.11.104
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