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CHARACTERIZATION OF HUMAN STRIATAL A(2)-ADENOSINE RECEPTORS USING RADIOLIGAND BINDING AND PHOTOAFFINITY LABELING
The adenosine agonist [(3)H]CGS21680 (2-[4-[[2-carboxyethyl]phenyl]ethylamino]-5'-N-ethylcarboxamidoadenosine) bound to A(2) receptors in human striatal membranes with a K(d) of 17.8±1.1 nM and a B(max) of 313± 10 fmol/mg protein. The addition of 100 μM GTP diminished both the affinity of agoni...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3429337/ https://ncbi.nlm.nih.gov/pubmed/1583620 |
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