The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development

Splenic marginal zone lymphoma (SMZL) is a B cell malignancy of unknown pathogenesis, and thus an orphan of targeted therapies. By integrating whole-exome sequencing and copy-number analysis, we show that the SMZL exome carries at least 30 nonsilent gene alterations. Mutations in NOTCH2, a gene requ...

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Main Authors: Rossi, Davide, Trifonov, Vladimir, Fangazio, Marco, Bruscaggin, Alessio, Rasi, Silvia, Spina, Valeria, Monti, Sara, Vaisitti, Tiziana, Arruga, Francesca, Famà, Rosella, Ciardullo, Carmela, Greco, Mariangela, Cresta, Stefania, Piranda, Daniela, Holmes, Antony, Fabbri, Giulia, Messina, Monica, Rinaldi, Andrea, Wang, Jiguang, Agostinelli, Claudio, Piccaluga, Pier Paolo, Lucioni, Marco, Tabbò, Fabrizio, Serra, Roberto, Franceschetti, Silvia, Deambrogi, Clara, Daniele, Giulia, Gattei, Valter, Marasca, Roberto, Facchetti, Fabio, Arcaini, Luca, Inghirami, Giorgio, Bertoni, Francesco, Pileri, Stefano A., Deaglio, Silvia, Foà, Robin, Dalla-Favera, Riccardo, Pasqualucci, Laura, Rabadan, Raul, Gaidano, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428941/
https://ncbi.nlm.nih.gov/pubmed/22891273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120904
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