Chemosensitisation of cancer cells by KU-0060648; a dual inhibitor of DNA-PK and PI-3K

DNA double strand breaks (DSBs) are the most cytotoxic lesions induced by topoisomerase II poisons. Non-homologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-PK activity. DNA-PKcs is structurally similar to PI-3K, which promotes cell survival and proliferation and is up-re...

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Autori principali: Munck, Joanne M., Batey, Michael A., Zhao, Yan, Jenkins, Helen, Richardson, Caroline J., Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J., Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall MB, Newell, David R, Smith, Graeme CM, Curtin, Nicola J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428850/
https://ncbi.nlm.nih.gov/pubmed/22576130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0535
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