COSTIMULATION BLOCKADE IN PIG ARTERY PATCH XENOTRANSPLANTATION – A SIMPLE MODEL TO MONITOR THE ADAPTIVE IMMUNE RESPONSE IN NONHUMAN PRIMATES

BACKGROUND: CD154-blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO pig artery transplantation model in baboons, we evaluated the efficacy of CD28/B7...

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Autori principali: Ezzelarab, MB, Ekser, B, Echeverri, G, Hara, H, Ezzelarab, C, Long, C, Bajona, P, Garcia, B, Murase, N, Ayares, D, Cooper, DKC
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428748/
https://ncbi.nlm.nih.gov/pubmed/22909135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1399-3089.2012.00711.x
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