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In Vivo-Validated Essential Genes Identified in Acinetobacter baumannii by Using Human Ascites Overlap Poorly with Essential Genes Detected on Laboratory Media

A critical feature of a potential antimicrobial target is the characteristic of being essential for growth and survival during host infection. For bacteria, genome-wide essentiality screens are usually performed on rich laboratory media. This study addressed whether genes detected in that manner wer...

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Main Authors: Umland, Timothy C., Schultz, L. Wayne, MacDonald, Ulrike, Beanan, Janet M., Olson, Ruth, Russo, Thomas A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428692/
https://ncbi.nlm.nih.gov/pubmed/22911967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00113-12
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