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A Class of Allosteric, Caspase Inhibitors Identified by High-Throughput Screening
Caspase inhibition is a promising approach for treating multiple diseases. Using a reconstituted assay and high-throughput screening, we identified a group of non-peptide caspase inhibitors. These inhibitors share common chemical scaffolds, suggesting same mechanism of action. They can inhibit apopt...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428514/ https://ncbi.nlm.nih.gov/pubmed/22795132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.007 |
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