Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

BACKGROUND: Metformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known. METHODS: To evaluate whether metformin induces anorexia via the hypothalamus, vario...

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Detalhes bibliográficos
Main Authors: Lee, Chang Koo, Choi, Yoon Jung, Park, So Young, Kim, Jong Yeon, Won, Kyu Chang, Kim, Yong Woon
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Diabetes Association 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428418/
https://ncbi.nlm.nih.gov/pubmed/22950061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4093/dmj.2012.36.4.293
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