Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene

CX3CR1 is an important chemokine receptor and regulates the chemotactic migration of pancreatic ductal adenocarcinoma (PDAC) cells. Up to now, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulates the expression of CX3CR1 in pancreatic cancer cells. When hypoxi...

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Hlavní autoři: Zhao, Tiansuo, Gao, Song, Wang, Xiuchao, Liu, Jingcheng, Duan, Yitao, Yuan, Zhanna, Sheng, Jun, Li, Shasha, Wang, Feng, Yu, Ming, Ren, He, Hao, Jihui
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428361/
https://ncbi.nlm.nih.gov/pubmed/22952674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043399
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