Challenges of modeling complex neuropsychiatric disorders with human induced pluripotent stem cells (hiPSCs): From “disease-in-a-dish” to personalized drug discovery

Identifying the molecular and cellular basis of complex neuropsychiatric disorders (cNPDs) has been limited by the inaccessibility of central neurons, variability within broad diagnostic classifications, and the interplay of genetic and environmental factors. Recent work utilizing neuronally differe...

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Bibliographic Details
Main Authors: Tobe, Brian T. D., Snyder, Evan Y., Nye, Jeffrey S.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428145/
https://ncbi.nlm.nih.gov/pubmed/21723195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2011.05.007
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