A Novel Origin for Granulovacuolar Degeneration in Aging and Alzheimer’s Disease: Parallels to Stress Granules

The phosphorylated ribosomal protein S6 (pS6) is associated with the 40S ribosomal subunit in eukaryotes and is thought to play a role in RNA storage, degradation, and re-entry into translation. In this study, we found pS6 localized to granulovacuolar degeneration (GVD) within pyramidal neurons. Imm...

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Auteurs principaux: Castellani, Rudy J., Gupta, Yashi, Sheng, Baiyang, Siedlak, Sandra L., Harris, Peggy L.R., Coller, Jeff M., Perry, George, Lee, Hyoung-gon, Tabaton, Massimo, Smith, Mark A., Wang, Xinglong, Zhu, Xiongwei
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428037/
https://ncbi.nlm.nih.gov/pubmed/21968813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.149
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