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Anesthetic Protection of Neurons Injured by Hypothermia and Rewarming: Roles of Intracellular Ca(2+) and Excitotoxicity

BACKGROUND: Mild hypothermia is neuroprotective following cerebral ischemia but surgery involving profound hypothermia (PH, temperature <18 °C) is associated with neurological complications. Rewarming (RW) from PH injures hippocampal neurons by glutamate excitotoxicity, N-methyl-D-aspartate recep...

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Detalhes bibliográficos
Main Authors: Bickler, Philip E., Warren, Daniel E., Clark, John P., Gabatto, Pablo, Gregersen, Maren, Brosnan, Heather
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428020/
https://ncbi.nlm.nih.gov/pubmed/22728782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318260a7b9
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