Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia

The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia. Furthermore, clozapine increases pregnenolone in rodent...

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Detalhes bibliográficos
Main Authors: Marx, Christine E, Keefe, Richard SE, Buchanan, Robert W, Hamer, Robert M, Kilts, Jason D, Bradford, Daniel W, Strauss, Jennifer L, Naylor, Jennifer C, Payne, Victoria M, Lieberman, Jeffrey A, Savitz, Adam J, Leimone, Linda A, Dunn, Lawrence, Porcu, Patrizia, Morrow, A Leslie, Shampine, Lawrence J
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427920/
https://ncbi.nlm.nih.gov/pubmed/19339966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.26
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