Common variants at 12q14 and 12q24 are associated with hippocampal volume

Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10(-7). Two additional samples (n=2,318) re...

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Main Authors: Bis, Joshua C., DeCarli, Charles, Smith, Albert Vernon, van der Lijn, Fedde, Crivello, Fabrice, Fornage, Myriam, Debette, Stephanie, Shulman, Joshua M., Schmidt, Helena, Srikanth, Velandai, Schuur, Maaike, Yu, Lei, Choi, Seung-Hoan, Sigurdsson, Sigurdur, Verhaaren, Benjamin F.J., DeStefano, Anita L., Lambert, Jean-Charles, Jack, Clifford R., Struchalin, Maksim, Stankovich, Jim, Ibrahim-Verbaas, Carla A., Fleischman, Debra, Zijdenbos, Alex, den Heijer, Tom, Mazoyer, Bernard, Coker, Laura H., Enzinger, Christian, Danoy, Patrick, Amin, Najaf, Arfanakis, Konstantinos, van Buchem, Mark A., de Bruijn, Renée F.A.G., Beiser, Alexa, Dufouil, Carole, Huang, Juebin, Cavalieri, Margherita, Thomson, Russell, Niessen, Wiro J., Chibnik, Lori B., Gislason, Gauti K., Hofman, Albert, Pikula, Aleksandra, Amouyel, Philippe, Freeman, Kevin B., Phan, Thanh G., Oostra, Ben A., Stein, Jason L., Medland, Sarah E., Vasquez, Alejandro Arias, Hibar, Derrek P., Wright, Margaret J., Franke, Barbara, Martin, Nicholas G., Thompson, Paul M., Nalls, Michael A., Uitterlinden, Andre G., Au, Rhoda, Elbaz, Alexis, Beare, Richard J., van Swieten, John C., Lopez, Oscar, Harris, Tamara B., Chouraki, Vincent, Breteler, Monique M.B., De Jager, Philip L., Becker, James T., Vernooij, Meike W., Knopman, David, Fazekas, Franz, Wolf, Philip A., van der Lugt, Aad, Gudnason, Vilmundur, Longstreth, W.T., Brown, Mathew A., Bennett, David A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Reinhold, Tzourio, Christophe, Launer, Lenore J., Ikram, M. Arfan, Seshadri, Sudha
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427729/
https://ncbi.nlm.nih.gov/pubmed/22504421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2237
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