I223R Mutation in Influenza A(H1N1)pdm09 Neuraminidase Confers Reduced Susceptibility to Oseltamivir and Zanamivir and Enhanced Resistance with H275Y

BACKGROUND: Resistance of pandemic A(H1N1)2009 (H1N1pdm09) virus to neuraminidase inhibitors (NAIs) has remained limited. A new mutation I223R in the neuraminidase (NA) of H1N1pdm09 virus has been reported along with H275Y in immunocompromised patients. The aim of this study was to determine the imp...

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Detalhes bibliográficos
Main Authors: LeGoff, Jérome, Rousset, Dominique, Abou-Jaoudé, Georges, Scemla, Anne, Ribaud, Patricia, Mercier-Delarue, Séverine, Caro, Valérie, Enouf, Vincent, Simon, François, Molina, Jean-Michel, van der Werf, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427316/
https://ncbi.nlm.nih.gov/pubmed/22936969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037095
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