DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status

We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high meth...

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Bibliografiska uppgifter
Huvudupphovsmän: Lauss, Martin, Aine, Mattias, Sjödahl, Gottfrid, Veerla, Srinivas, Patschan, Oliver, Gudjonsson, Sigurdur, Chebil, Gunilla, Lövgren, Kristina, Fernö, Mårten, Månsson, Wiking, Liedberg, Fredrik, Ringnér, Markus, Lindgren, David, Höglund, Mattias
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2012
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427281/
https://ncbi.nlm.nih.gov/pubmed/22705924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.20837
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