DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status

We assessed DNA methylation and copy number status of 27,000 CpGs in 149 urothelial carcinomas and integrated the findings with gene expression and mutation data. Methylation was associated with gene expression for 1,332 CpGs, of which 26% showed positive correlation with expression, i.e., high meth...

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Detalhes bibliográficos
Main Authors: Lauss, Martin, Aine, Mattias, Sjödahl, Gottfrid, Veerla, Srinivas, Patschan, Oliver, Gudjonsson, Sigurdur, Chebil, Gunilla, Lövgren, Kristina, Fernö, Mårten, Månsson, Wiking, Liedberg, Fredrik, Ringnér, Markus, Lindgren, David, Höglund, Mattias
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427281/
https://ncbi.nlm.nih.gov/pubmed/22705924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.20837
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