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Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3
We have developed a targeted method to quantify all combinations of methylation on an H3 peptide containing lysines 27 and 36 (H3K27-K36). By using stable isotopes that separately label the histone backbone and its methylations, we tracked the rates of methylation and demethylation in myeloma cells...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427122/ https://ncbi.nlm.nih.gov/pubmed/22869745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205707109 |
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