Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

Recently, hepatic peroxisome proliferator-activated receptor (PPAR)γ has been implicated in hepatic lipid accumulation. We found that the C3H mouse strain does not express PPARγ in the liver and, when subject to a high-fat diet, is resistant to hepatic steatosis, compared with C57BL/6 (B6) mice. Ade...

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Autori principali: Lee, Yoo Jeong, Ko, Eun Hee, Kim, Ji Eun, Kim, Eunha, Lee, Hyemin, Choi, Hyeonjin, Yu, Jung Hwan, Kim, Hyo Jung, Seong, Je-Kyung, Kim, Kyung-Sup, Kim, Jae-woo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427113/
https://ncbi.nlm.nih.gov/pubmed/22869740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203218109
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