Keap1 degradation by autophagy for the maintenance of redox homeostasis

The Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) system is essential for cytoprotection against oxidative and electrophilic insults. Under unstressed conditions, Keap1 serves as an adaptor for ubiquitin E3 ligase and promotes proteasomal degradation of Nrf2, but Nrf2 is...

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Autors principals: Taguchi, Keiko, Fujikawa, Nanako, Komatsu, Masaaki, Ishii, Tetsuro, Unno, Michiaki, Akaike, Takaaki, Motohashi, Hozumi, Yamamoto, Masayuki
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427110/
https://ncbi.nlm.nih.gov/pubmed/22872865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121572109
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