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Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli

Although microbial metabolic engineering has traditionally relied on rational and knowledge-driven techniques, significant improvements in strain performance can be further obtained through the use of combinatorial approaches exploiting phenotypic diversification and screening. Here, we demonstrate...

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Autors principals: Santos, Christine Nicole S., Xiao, Wenhai, Stephanopoulos, Gregory
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427108/
https://ncbi.nlm.nih.gov/pubmed/22869698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206346109
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