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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell motility in vivo, the underlying mechanism of cancer cell intravasation remains largely unknown. We developed a microfluidic-based assay to recrea...

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Bibliographic Details
Main Authors: Zervantonakis, Ioannis K., Hughes-Alford, Shannon K., Charest, Joseph L., Condeelis, John S., Gertler, Frank B., Kamm, Roger D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427099/
https://ncbi.nlm.nih.gov/pubmed/22869695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210182109
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