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Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. Here we report crystal structures of the galactofuranose biosynthetic enzyme UDP-galactopyranose mutase (UGM) from T. cruzi, which are the first structures of this enzyme from a protozoan parasite. UGM...

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Bibliografske podrobnosti
Main Authors: Dhatwalia, Richa, Singh, Harkewal, Oppenheimer, Michelle, Sobrado, Pablo, Tanner, John J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426654/
https://ncbi.nlm.nih.gov/pubmed/22646091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300498c
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