Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a retinoid-dependent type-2 immune response elici...

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Detalhes bibliográficos
Main Authors: Broadhurst, Mara J., Leung, Jacqueline M., Lim, K. C., Girgis, Natasha M., Gundra, Uma Mahesh, Fallon, Padraic G., Premenko-Lanier, Mary, McKerrow, James H., McCune, Joseph M., Loke, P'ng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426520/
https://ncbi.nlm.nih.gov/pubmed/22927819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002883
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