Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing

Large conductance, voltage- and Ca(2+)-activated K(+) (BK) channels in inner hair cells (IHCs) of the cochlea are essential for hearing. However, germline deletion of BKα, the pore-forming subunit KCNMA1 of the BK channel, surprisingly did not affect hearing thresholds in the first postnatal weeks,...

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Main Authors: Kurt, Simone, Sausbier, Matthias, Rüttiger, Lukas, Brandt, Niels, Moeller, Christoph K., Kindler, Jennifer, Sausbier, Ulrike, Zimmermann, Ulrike, van Straaten, Harald, Neuhuber, Winfried, Engel, Jutta, Knipper, Marlies, Ruth, Peter, Schulze, Holger
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425825/
https://ncbi.nlm.nih.gov/pubmed/22691916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-200535
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