Carbodiimide modification of superhelical PM2 DNA: considerations regarding reaction at unpaired bases and the unwinding of superhelical DNA with chemical probes.

Superhelical PM2 DNA I can be modified with N-cyclohexyl-N'-beta-(4-methylmorpholinium)ethyl carbodiimide (CMC). The transition of the sedimentation coefficient uncorrected for buoyant density change (S20,*) vs. % reactivity in terms of base pairs shows the following characteristics. The S20,*...

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Bibliographic Details
Main Authors: Lebowitz, J, Chaudhuri, A K, Gonenne, A, Kitos, G
Format: Artigo
Language:Inglês
Published: 1977
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC342515/
https://ncbi.nlm.nih.gov/pubmed/896472
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