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Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer formation and dissociation linked to ATP binding and...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Medknow Publications & Media Pvt Ltd
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3425041/ https://ncbi.nlm.nih.gov/pubmed/22924067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1817-1737.98842 |
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