Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells

The p16(INK4A) (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is often considered to be critical for establishing...

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Hlavní autoři: Mirzayans, Razmik, Andrais, Bonnie, Hansen, Gavin, Murray, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424640/
https://ncbi.nlm.nih.gov/pubmed/22924132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/951574
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