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GB virus C envelope protein E2 inhibits T cell receptor induced IL-2 production and alters IL-2 signaling pathways

GB virus type C (GBV-C) viremia is associated with reduced CD4+ T cell expansion following Interleukin 2 (IL-2) therapy and with a reduction in T cell activation in HIV-infected individuals. Mechanism(s) by which GBV-C might alter T-cell activation or IL-2 signaling have not been studied. Here, we a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bhattarai, Nirjal, McLinden, James H., Xiang, Jinhua, Kaufman, Thomas M., Stapleton, Jack T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424397/
https://ncbi.nlm.nih.gov/pubmed/22844114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201324
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