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CD8(+)CD45RA(+)CCR7(+)FOXP3(+) T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells
CD8 T cells stimulated with a suboptimal dose of anti-CD3 antibodies (100 pg/ml) in the presence of IL-15 retain a naïve phenotype with expression of CD45RA, CD28, CD27 and CCR7 but acquire new functions and differentiate into immunosuppressive T cells. CD8(+)CCR7(+) Tregs express FOXP3 and prevent...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3424334/ https://ncbi.nlm.nih.gov/pubmed/22821963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200122 |
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