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Rbm15-Mkl1 Interacts with the Setd1b Histone H3-Lys4 Methyltransferase via a SPOC Domain That Is Required for Cytokine-Independent Proliferation

The Rbm15-Mkl1 fusion protein is associated with acute megakaryoblastic leukemia (AMKL), although little is known regarding the molecular mechanism(s) whereby this fusion protein contributes to leukemogenesis. Here, we show that both Rbm15 and the leukemogenic Rbm15-Mkl1 fusion protein interact with...

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Sonraí Bibleagrafaíochta
Main Authors: Lee, Jeong-Heon, Skalnik, David G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424240/
https://ncbi.nlm.nih.gov/pubmed/22927943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042965
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