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8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT(1A) receptors in the nucleus tractus solitarius

Intravenous bolus injection of morphine causes a vagal-mediated brief apnea (∼3 s), while continuous injection, via action upon central μ-opioid receptor (MOR), arrests ventilation (>20 s) that is eliminated by stimulating central 5-hydroxytryptamine 1A receptors (5HT(1A)Rs). Bronchopulmonary C-f...

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Detalhes bibliográficos
Main Authors: Zhuang, Jianguo, Zhang, Zhenxiong, Zhang, Cancan, Xu, Fadi
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423994/
https://ncbi.nlm.nih.gov/pubmed/22696579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00016.2012
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