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Cellular mechanisms of β-amyloid production and secretion

The major constituent of senile plaques in Alzheimer’s disease is a 42-aa peptide, referred to as β-amyloid (Aβ). Aβ is generated from a family of differentially spliced, type-1 transmembrane domain (TM)-containing proteins, called APP, by endoproteolytic processing. The major, relatively ubiquitous...

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Bibliografske podrobnosti
Main Authors: Sinha, Sukanto, Lieberburg, Ivan
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC34239/
https://ncbi.nlm.nih.gov/pubmed/10500121
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