RNA Interference Trigger Variants: Getting the Most Out of RNA for RNA Interference-Based Therapeutics

The manifestation of RNA interference (RNAi)-based therapeutics lies in safe and successful delivery of small interfering RNAs (siRNAs), the molecular entity that triggers and guides sequence-specific degradation of target mRNAs. Optimizing the chemistry and structure of siRNAs to achieve maximum ef...

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Bibliographic Details
Main Authors: Snead, Nicholas M., Rossi, John J.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423874/
https://ncbi.nlm.nih.gov/pubmed/22703279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2012.0361
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