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A phylogenetic analysis of normal modes evolution in enzymes and its relationship to enzyme function
Since the dynamic nature of protein structures is essential for enzymatic function, it is expected that the functional evolution can be inferred from the changes in the protein dynamics. However, dynamics can also diverge neutrally with sequence substitution between enzymes without changes of functi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423504/ https://ncbi.nlm.nih.gov/pubmed/22651983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.028 |
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