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Biochemical Dynamics Relevant to the Safety of Low-Dose, Intraclot Alteplase for Deep Vein Thrombosis

Intraclot tPA has been shown to be an effective treatment for DVT (Radiology 2008;246:619 & J Vasc Interv Radiol 2011;22:1107). We sought to correlate pharmacokinetics of tPA, fibrinogen, fibrinolytic inhibitors, and D-dimers with the safety and efficacy of intra-clot tPA. Thirty subjects receiv...

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Autors principals: Lozier, Jay Nelson, Cullinane, Ann, Nghiem, Khanh, Chang, Richard, Horne, McDonald K.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423482/
https://ncbi.nlm.nih.gov/pubmed/22683421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2012.01.025
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