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Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cells
INTRODUCTION: ZEB1 is overexpressed in patients with severe hypospadias. We examined the interaction between ZeB1 and the androgen receptor (AR) in vitro and the expression of AR in boys with hypospadias. RESULTS: ZEB1 and AR colocalize to the nucleus. Estrogen upregulated ZEB1 and AR expression. Ch...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423458/ https://ncbi.nlm.nih.gov/pubmed/22391641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2011.49 |
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