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(S)-α-Chlorohydrin Inhibits Protein Tyrosine Phosphorylation through Blocking Cyclic AMP - Protein Kinase A Pathway in Spermatozoa

α-Chlorohydrin is a common contaminant in food. Its (S)-isomer, (S)-α-chlorohydrin (SACH), is known for causing infertility in animals by inhibiting glycolysis of spermatozoa. The aim of present work was to examine the relationship between SACH and protein tyrosine phosphorylation (PTP), which plays...

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Main Authors: Zhang, Hao, Yu, Huan, Wang, Xia, Zheng, Weiwei, Yang, Bei, Pi, Jingbo, He, Gengsheng, Qu, Weidong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423423/
https://ncbi.nlm.nih.gov/pubmed/22916194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043004
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