Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation

BACKGROUND: Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimental studies have shown that spinal graft...

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Hauptverfasser: Hefferan, Michael P., Galik, Jan, Kakinohana, Osamu, Sekerkova, Gabriela, Santucci, Camila, Marsala, Silvia, Navarro, Roman, Hruska-Plochan, Marian, Johe, Karl, Feldman, Eva, Cleveland, Don W., Marsala, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423406/
https://ncbi.nlm.nih.gov/pubmed/22916141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042614
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