Constitutive Activation of STAT5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to EGFR Targeting

PURPOSE: Signal Transducer and Activator of Transcription 5 (STAT5) is activated in squamous cell carcinoma of the head and neck (SCCHN), where targeting STAT5 inhibits tumor growth in vitro and in vivo. The role of STAT5 activation in carcinogenesis, tumor progression and response to therapy remain...

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Detalhes bibliográficos
Main Authors: Koppikar, Priya, Lui, Vivian Wai Yan, Man, David, Xi, Sichuan, Chai, Raymond Liu, Nelson, Elizabeth, Tobey, Allison BJ, Grandis, Jennifer Rubin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422894/
https://ncbi.nlm.nih.gov/pubmed/19047094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1328
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